Daniel G. Stover, MD

Daniel G. Stover, MD

Dana-Farber Cancer Institute

Daniel G Stover, M.D.

The host immune system is critical in the control and elimination of tumors in many cancer types. In breast cancer, tumor infiltrating immune cells have been associated with both response to chemotherapy and overall outcome for patients. Understanding what immune cell populations infiltrate tumors may help guide which patients are likely to benefit from chemotherapy and provide targets to improve the efficacy of chemo- and other therapies. Within breast cancer, estrogen receptor (ER)-positive breast cancers comprise the majority of all breast cancers but the role of immune cells remains less well-understood relative to other breast cancer subtypes.

We developed evidence that immune cells play a critical role in response to chemotherapy in a subset of patients with ER-positive breast cancers. As a Terri Brodeur Fellow, Dr. Stover will integrate large, publicly available datasets to investigate immune cell signatures in thousands of breast tumors. In parallel, he will work to understand immune cell subsets in breast cancer biopsies of patients on clinical trials of chemotherapy and immune-directed therapies. Ultimately, his goal is to develop biologically rational, immune-based biomarkers to guide therapy, including chemotherapy and immune-directed therapies.

Dr. Stover is a cum laude graduate of Princeton University and received his M.D. from Vanderbilt University where he was named to AOA Honor Medical Society. Dr. Stover was a resident in internal medicine at Vanderbilt University Medical Center and was selected to serve as the Hugh J. Morgan Chief Resident in Medicine. He completed his fellowship in medical oncology at the Dana-Farber Cancer Institute/Massachusetts General Hospital/Harvard Cancer Center program. Dr. Daniel Stover is currently an Instructor in Medicine at Dana-Farber Cancer Institute and postdoctoral research fellow in the lab of Joan Brugge, PhD at Harvard Medical School.

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